Preheat your oven to 375°F (190°C). Lightly grease a deep 9-inch pie dish to ensure your pie releases easily after baking.

Roll out your pie crust on a lightly floured surface and fit it snugly into the prepared pie dish. Prick the bottom with a fork and blind-bake for about 7-8 minutes until slightly golden.

In a large skillet over medium-high heat, add the ground beef and Italian sausage. Break apart as it cooks, browning for about 5-7 minutes until fully cooked. Drain excess grease.

Lower the heat to medium and add the diced onion and minced garlic to the skillet. Sauté for about 3-4 minutes until they soften. Stir in Italian seasoning, salt, and pepper.

Pour in the crushed tomatoes and tomato paste, stirring to create a thick mixture. Simmer on low for about 5 minutes.

Spread a layer of meat mixture over the pre-baked crust. Add pepperoni slices, followed by shredded mozzarella and cheddar cheese. Repeat layers until all ingredients are used.

Place the assembled pie in the preheated oven and bake for 25-30 minutes until the top is golden brown and bubbly.

Remove the pie from the oven and let it rest for about 10 minutes before slicing.

Slice your pie into wedges and serve warm.